Further analysis of individual genes of biological relevance to NAFLD in HFD-fed C57BL/6J highlighted the coordinated transcription upregulation of beta catenin (Catnb) and caveolins (Cav1, Cav2) which have been associated with steatohepatitis [24,25] and may underlie mechanisms compensating liver structural alterations. The gene discussed is CAV1; the disease is metabolic dysfunction-associated steatotic liver disease.