CRP and irritable bowel syndrome: C-reactive peptide (CRP) is a serum acute phase inflammatory protein that is used to detect systemic inflammatory disease, including GI disease, in both humans and nonhuman primates [45], [46] (Figure S2C), secretory IgA (sIgA) is a component of mucosal immunity that can serve as a fecal indicator of infectious enterocolitis [47]–[49] (Figure S2D), and calprotectin is a fecal marker produced by neutrophils used to detect irritable bowel syndrome [45], [50] (Figure S2E).