In contrast, co-transfer of Nod2 deficient or wild type naive T cells with either Nod2 deficient or wild type activated/memory T cells suppressed the development of colitis as indicated by the increased weight gain, the lower colon pathology scores (pathology scores < 4) and the decreased weight to length colon ratio observed in recipient mice (Figure 3A-C). Here, NOD2 is linked to colitis.