Therefore, the present study has been designed for the first time to investigate (1) whether naringin, a powerful natural antioxidant, reverse cardiac dysfunction and morpho-histological changes in in vivo model of MI by alteration of the redox state through regulation of molecular chaperones Hsp27 and 70; or (2) whether this response is through regulation of p-Akt/p-eNOS signaling as well as reduced NO inactivation, and thereby increased NO bioavailability; or (3) whether this cardioprotective effects is through controlling the apoptotic, IKK-β/NF-κB and MAPKs signaling pathway. Here, NFKB1 is linked to myocardial infarction.