More importantly, the iron plus VB12 supplementation greatly improved the bone marrow G1 and G2 erythroblast percentage, the erythroblast apoptosis and proliferation (Figure 5 A~C), Iron and VB12 combined supplementation greatly rescued the anemia phenotype in MCPIP1-/- mice (Figure 5D). The gene discussed is ZC3H12A; the disease is anemia.