The kinetics of CP accumulation was different depending on the localization studied (Figure 4): The ratios of the plasma CP content of CKD mice to that of the sham group was maximal at 5 weeks (ratio HCit in CKD/ HCit in ShSh: 2.7) but decreased to reach a steady-state level at 20 weeks (ratio: 2.0). The gene discussed is CP; the disease is chronic kidney disease.