These results indicating that 20-HETE potentiates the vasoconstrictor response to ANG II in renal interlobular arteries are consistent with previous findings of Alonso-Galicia et al (2002), who reported that administration of a 20-HETE inhibitor attenuated the acute pressor response to ANG II in rats in vivo by about 50% and chronic blockade attenuated the development of ANG II induced hypertension [1]. Here, AGT is linked to hypertensive disorder.