Early studies on these genes revealed the expression of different DN isoforms of Ikaros (Ik-4, Ik-7 and Ik-8), as well as insertions of 60 bp in Exon 2 and deletions of 30 bp in Exon 6, in infants diagnosed with ALL [12-14]. This evidence concerns the gene IKZF1 and acute lymphoblastic leukemia.