Several polymorphisms are present in NFKB1 (1900 SNPs) and NFKBIA (158 SNPs) according to dbSNP database (www.ncbi.nlm.nih.gov/snp), however, previous studies have extensively explored role of common polymorphic variants in promoter region of NFKB1 (-94 ATTG ins/del; rs28720239) and NFKBIA (-826 C>T; rs2233406) and 3’UTR region of NFKBIA (3’UTR A>G; rs696) in susceptibility and prognosis of various cancers [24–29]. Here, NFKBIA is linked to cancer.