NFKBIA and neoplasm: Association of the polymorphisms with tumour location showed significant reduced risk of upper and lower third esophageal tumours with NFKBIA -826 CT+TT and 3’UTR AG+GG genotype respectively (OR = 0.41, 95% CI = 0.21-0.80, P = 0.009, q = 0.019 and OR = 0.52, 95% CI = 0.29-0.93, P = 0.028, q = 0.072 respectively) (Table 6).