Our meta-analysis found the addition of Bev led to greater risk for non-CNS bleeding (RR, 3.63; CI, 1.81 to 7.29; P = .000), hypertension of grade ≥ 2 (RR, 4.90; CI, 3.83 to 6.25; P = .000), ATE (RR, 2.29; CI, 1.33 to 3.94; P = .003), gastrointestinal perforation (GIP) (RR, 2.90; CI, 1.44 to 5.82; P = .003), and proteinuria of grade ≥3 (RR, 6.63; CI, 3.17 to 13.88; P = .000). This evidence concerns the gene GIP and Hypertension.