It was observed that TNF-α, IL-10, ICAM-1 and VCAM-1 were the 4 best individual predictors of complicated vivax malaria with AUROC of 0.89 (95% CI: 0.84 - 0.94), 0.79 (95%CI: 0.73- to 0.86), 0.63 (0.55-0.71) and 0.84 (95% CI: 0.78- 0.90) respectively. The gene discussed is TNF; the disease is Plasmodium vivax malaria.