ANXA5 and neoplasm: Furthermore, our results are consistent with a previous report, which showed that tumor uptake of 99mTc-HYNIC-annexin A5 increased significantly after a single dose of cyclophosphamide treatment (150 mg/kg, i.p.)in KDH-8 hepatoma tumor-bearing rats, and the increase was concordant with the number of TUNEL-positive cells in the tumor [19].