When 99mTc-C3(BHam)2-annexin A5 was administered into tumor-bearing mice after 24 h of the first 5-FU treatment (at 7 days after inoculation), the accumulation of 99mTc-C3(BHam)2-annexin A5 in tumor tissue was significantly higher than that of the untreated group (Figure 3A). The gene discussed is ANXA5; the disease is neoplasm.