ANXA5 and neoplasm: In addition, to evaluate whether 99mTc-C3(BHam)2-annexin A5 is able to detect apoptosis as an early response of chemotherapy, the relationship between the therapeutic effects of chemotherapy and the tumor accumulation of 99mTc-C3(BHam)2-annexin A5 after injection of 5-FU in tumor-bearing mice, and the correlation between tumor accumulation or intratumoral distribution of 99mTc-C3(BHam)2-annexin A5 and the number of TUNEL-staining positive cells were evaluated.