To investigate whether the intratumoral localization of 99mTc-C3(BHam)2-annexin A5 correlated with the sites of drug-induced apoptosis cells, we divided the autoradiographic and TUNEL-staining images of tumor sections using grids (grid size; 0.45 mm×0.55 mm) and determined the radioactivity and number of TUNEL-positive cells in each grid. This evidence concerns the gene ANXA5 and neoplasm.