Interestingly, the up-regulation of DLGAP5 expression in HCCs was not statistically correlated with patient gender, age, tumor size, family history, HBsAg expression, liver cirrhosis, history of wine-drinking, history of smoking, BCLC stage, or development of distant metastasis or lymph node metastasis (P>0.05). This evidence concerns the gene DLGAP5 and cirrhosis of liver.