The obtained data showed that the density of COX-2+ cancer cells was significantly higher in the high MUC2 expression group (p=0.017, Student’s t test, Figure 4), with a significantly increased local concentration of PGE2 detected using the enzyme-linked immunosorbent assay (ELISA) (methods for performing ELISA were provided by Materials and Methods S2 in File S1, the results of the PGE2 ELISA experiment were provided by Figure S2 in File S2) compared to the low MUC2 expression group. Here, PTGS2 is linked to cancer.