As shown in Figure 2, we found that, regardless of the overall MUC2 expression level, the density of CD68+COX-2+ TAMs was significantly higher in the cancer islets, in which MUC2 molecules were vigorously secreted, than in the stromal regions, in which MUC2 molecules were scarcely secreted (p<0.001, ANOVA, Figure 2). Here, PTGS2 is linked to cancer.