CD4 and diabetes mellitus: Figure 2 shows that the increased risk from inadequate exercise is significantly greater than in diabetics than non-diabetics, which could reflect in part the different effects of exercise on regulatory T-cells in type 2 diabetes mellitus and non-diabetic subjects [13]. Tregs, CD4+CD25+ cells that express Forkhead Box 3 (FoxP3), are lymphocyte-responsible for suppressing excessive immune responses. Exercise is reported to increase their FoxP3 expression in type 2 diabetes mellitus, but not healthy controls [44].