It has been reported that extracellular hyperglycemia causes intracellular hyperglycemia in β-cells leading to the induction of ROS [5] which becomes exacerbated, through lack of antioxidant enzymes such as catalase, glutathione peroxidase, and superoxide mutase in the pancreatic islet of diabetic animals [12]. This evidence concerns the gene CAT and Hyperglycemia.