We and others have shown that DC differentiation from monocytes can be blocked by tumor-derived soluble factors (most notably IL-10, IL-6, or PGE2) resulting in the development of CD14+ macrophage-like cells with poor T cell stimulatory abilities (so-called M2-type macrophages) and with T cell suppressive activity (Figure 2) (29–32). The gene discussed is IL10; the disease is neoplasm.