TNF and neoplasm: This is in line with the transcriptional and cytokine release profiles we observed for CD14+ IL-10-conditioned DC, which revealed coordinated expression of HIF1α, TGFβ, VEGFA, MMP3, MMP9, IL-8, and TNFα, all of which can contribute to such tumor-promoting processes as endothelial cell migration and proliferation and tumor growth and invasion (28).