Among a panel of tumor-associated suppressive factors, we found IL-10 uniquely able to convert DCs to immature macrophage-like cells in two human model systems: (1) a physiologically highly relevant skin explant model in which we studied the phenotypic and functional traits of “crawl-out” myeloid cells (13) and (2) an in vitro model of tumor-conditioned DC maturation in which we functionally assessed CD14− and CD14+ DC that had developed from monocyte-derived DC (MoDC) during IL-10-exposed maturation (17). This evidence concerns the gene CD14 and neoplasm.