As BBS1 is involved in the trafficking of MCHR1 (54), this ventriculomegaly may be partly due to a defect in MCHR1 expression by ciliated ependymal cells, However, it is worth mentioning that the whole distribution of MCHR1 throughout the brain of BBS mouse models is still lacking. The gene discussed is MCHR1; the disease is Ventriculomegaly.