SLC9A1 and heart failure: In a number of these animal models chronic NHE-1 inhibition prevented (Kusumoto et al., 2001; Sandmann et al., 2001; Baartscheer et al., 2005) or even reversed the development of hypertrophy or heart failure(Camilion de Hurtado et al., 2002; Cingolani et al., 2003; Baartscheer et al., 2008; Baartscheer and van Borren, 2008).