Results showed that, whereas no differences were seen when cells were stimulated with non-immunogenic peptides (data not shown), Aβ42-stimulated-BDNF-producing CD4+ T lymphocytes were significantly reduced in AD compared to aMCI (p = 0.003); interestingly, and confirming the increased inflammatory status of AD, IFNγ-producing-CD8+ T lymphocytes were increased in AD compared to AMCI individuals (p = 0.012). This evidence concerns the gene CD8A and Alzheimer disease.