SLC1A2 and Huntington disease: Several studies have suggested that in the HD striatum reduced glutamate uptake through GLT-1 may impair the capacity of astrocytes to support normal levels of neuronal activity (Lievens et al., 2001; Behrens et al., 2002; Miller et al., 2008; Faideau et al., 2010; Petr et al., 2013), but it is not yet known as to what extent tonic GABA effects, in general, and GAT-3 function, in particular, were altered in symptomatic HD.