The confirmed presence of secretory molecules derived from adipocytes, such as proinflammatory cytokines (e.g., tumor necrosis factor-alpha [TNF-α] and interleukin-6 [IL-6]), constitutes the unique endocrine function of adipose and provides valuable pathophysiological insight regarding obesity and its comorbidities [7]. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.