In obese Zucker fatty rats (spontaneous type 2 diabetes animals) fed a magnesium-supplemented diet for 6 weeks beginning at 6 weeks old showed lower fasting and fed-state blood glucose concentrations, better glucose disposal, higher insulin and C-peptide concentrations, and increased pancreatic GLUT2 and insulin mRNA expression than animals on the control diet [27]. This evidence concerns the gene INS and type 2 diabetes mellitus.