Importantly, in such multivariate analysis, including SOFA and SAPS II scores, decreased CD74 mRNA level (Odds Ratio = 3.4, 95% CI: 1.2 to 9.8, P = 0.026) or diminished mHLA-DR (Odds Ratio = 7.8, 95% CI: 2.6 to 23.4, P <0.001) remained significantly associated with a higher risk of death after septic shock (Table 4). This evidence concerns the gene CD74 and Shock.