In this study, we report for the first time an association between BRCA1 and AGTR1 status in ovarian cancer: (i) AGTR1 expression was increased in non-BRCA1-mutated ovarian cancer, but BRCA1 dysfunction (such as via BRCA1 mutation or promoter hypermethylation) was associated with decreased AGTR1 levels; (ii) there was a positive correlation between BRCA1 and AGTR1 expression in ovarian cancer specimens; and (iii) BRCA1 activation was effective at inducing AGTR1 expression in primary ovarian cancer cells. The gene discussed is BRCA1; the disease is ovarian carcinoma.