In this study, we report an association between BRCA1 and EGFR status in ovarian cancer cells: (i) although EGFR expression was increased in BRCA1- and BRCA2-mutated ovarian cancer, only the BRCA1-mutated group exhibited dramatically increased expression of EGFR compared with the non-BRCA1-mutated group; (ii) BRCA1 inactivation (BRCA1 mutation or promoter hypermethylation) dramatically increased the expression of EGFR; and (iii) BRCA1 knockdown was an effective way to activate the EGFR gene. This evidence concerns the gene BRCA2 and ovarian carcinoma.