EGFR and cancer: Notably, emerging evidence has established that: (i) EGFR is a potential link between genetic and environmental interactions[7]; (ii) EGFR and BRCA1 can be found in the same protein complex, and convergence exists between EGFR- and BRCA1-related signaling pathways[8,9]; and (iii) BRCA1 mutations are vulnerable to the development of EGFR-positive cancers[10].