STAT3 and endometrial cancer: Moreover, inhibition of STAT3 by small interference RNA (siRNA) (Figure 3D) elevated the miR-204-5p expression in IshikawaTrkB and HEC-1B cells (P < 0.05) (Figure 3E), indicating that, indeed, TrkB activates the JAK2/STAT3 pathway in endometrial cancer cells.