APOB and coronary artery disorder: In a study of the genotypes at three polymorphic sites of ApoB (the indelat the signal peptide, XbaI at exon 26, and EcoRI at exon 29), Machado et al. [122] reported the simultaneous presence of the rare X+ and Del alleles (X+Del haplotype) in males with CHD was associated with significantly high serum levels of total cholesterol (P < 0.01), TG (P < 0.05), and LDL-cholesterol (P < 0.05) and with a high total cholesterol/HDL-C ratio (P < 0.05).