Ageing is characterized by a Ifng driven chronic, low grade, Th-1 type inflammation which could contribute to the onset of major age-related psychiatric conditions (such as depression, anxiety, insomnia, and cognitive impairment) and medical diseases (such as cardiovascular diseases, neurodegeneration, osteoarthritis and osteoporosis, and diabetes) [30, 31]. This evidence concerns the gene NELFCD and major depressive disorder.