Excluding age from our model, increased year 1 plasma bFGF (>4 pg/mL) appeared to be a nearly significant predictor (HR 2.439; 95% CI 1.522–3.356; P = 0.0518) of time to first post-year 1 CVD occurrence (22 events in 71 patients) among patients with baseline diabetes duration ≥15 years. This evidence concerns the gene FGF2 and diabetes mellitus.