In support of the latter two possibilities, our preliminary experiments indicated that even low concentrations (1–2 μg/mL) of protein A eluates from subsets of advanced adult type 1 autoimmune diabetes (n = 2) or advanced adult type 2 DM having chronic kidney disease (n = 3) could be completely neutralized by co-incubating endothelial cells with specific anti-bFGF antibodies. The gene discussed is FGF2; the disease is chronic kidney disease.