Similar importance is now attributed to the phenomenon of angiogenesis, which has the vascular endothelial growth factor (VEGF) as the key biomarker, a peptide growth factor secreted by vascular endothelial cells that stimulates vasculogenesis and angiogenesis, which has been involved in the pathogenesis of cardiovascular diseases, such as atherosclerosis [67], as well as to the intracellular adhesion molecules, such as ICAM-1, which has been associated with the severity of atherosclerosis and cardiovascular events [68]. The gene discussed is ICAM1; the disease is cardiovascular disorder.