Majority of the most upregulated genes have been previously described (e.g., HIG2, EGLN3, IKBIP, and VIM), but we also found a few genes with less well-described function in ccRCC, like alpha-(1,3)-fucosyltransferase 11 (FUT11), shown to be expressed in HEK293 cell line, and E3 ubiquitin ligase RNF149 [21]. This evidence concerns the gene EGLN3 and nonpapillary renal cell carcinoma.