Similar to the MDA-MB-468 xenograft mouse model, PHGDH shRNA also did not inhibit tumor growth significantly in HCC1806 and BT-20 xenograft mouse models (Fig. 4C and E), although robust PHGDH knockdown was also achieved in either the mRNA or protein level (Fig. 4D and F). Here, PHGDH is linked to neoplasm.