Consistently, the positive correlation between loss of E-cadherin and ERK activation was also observed in the disseminating cancer cells of NSCLC patients, demonstrating that the EGFR-MEK/ERK axis would be a promising target for attenuating deviant MMP2 expression and the subsequent invasive trait in EMT-induced NSCLCs. This evidence concerns the gene CDH1 and non-small cell lung carcinoma.