Our data suggest that EGFR-dependent signaling would be an important therapeutic target for NSCLC treatment, based on the results such as the requirement of MEK/ERK signaling in the invasive properties of EMT-induced A549 cells (Fig. 5) and the local activation of ERK at the invasive tumor fronts (Fig. 7). Here, EGFR is linked to non-small cell lung carcinoma.