M2-like TAM have high levels of mannose receptor-1 (MRC1/CD206), arginase-1 (Arg1), IL-10 and chemokines CCL22 and CCL17, whereas anti-tumor M1-like TAM express high interferon (IFN)γ and IL-1α/β levels; TNFα marks both M1- and M2-polarized TAM [6]. Here, TNF is linked to neoplasm.