CD8A and neoplasm: In summary, our findings indicate that statin treatment elicits a triple program that (1) improves vascular function, hence increasing the penetration of cytotoxic drugs into the tumor parenchyma, (2) enhances CD8+ T cell infiltration into the tumor, thus altering the effector:suppressor cell balance in the tumor stroma, and (3) re-educates TAM to an M1-like phenotype, which might rectify aberrant angiogenesis and create an environment prone to antitumor immunity rather than immune suppression.