To clarify the role of Smad7 in CRC cell growth, Halder et al., overexpressed Smad7 in FET, a CRC cell line, and showed that Smad7 enhanced anchorage-independent cell growth, favored the formation of colonies on soft agar and increased resistance against apoptosis through a mechanism dependent on suppression of TGF-β signaling. Here, SMAD7 is linked to colorectal carcinoma.