Supplementation of CPE prevented the weight gain and reduced serum glucose, TC and liver TG level of HF-induced obesity mice, inhibited the mRNA expression of ap2, LXRβ and LPL in mouse liver; while supplementation of CFSE reduced mouse weight, serum glucose, serum LDL-c and liver TC level, showing inhibition of the mRNA expression of PPARγ, ap2, FAS and ApoE in mouse liver. This evidence concerns the gene NR1H2 and obesity due to melanocortin 4 receptor deficiency.