In RSV virions, the presence of an inner layer of membrane-associated M protein has been shown to correlate with partial ordering of the glycoprotein spikes (Liljeroos et al., 2013), suggesting that in the context of viral infection, M would bind membranes at sites enriched in viral glycoproteins and the concave face would be involved in binding the conserved cytoplasmic tails of F and/or G proteins. The gene discussed is ART4; the disease is viral infectious disease.