Once TAMs are recruited to the hypoxic areas, TAMs respond to hypoxia by upregulating hypoxia-inducible transcription factors (e.g., HIF-1α) for metabolic adaption, leading to an increase in transcription of a number of genes (e.g., VEGF, CXCL8) involved in regulating tumor vascularization [51,70,104]. This evidence concerns the gene VEGFA and neoplasm.