STAT3-regulated factors produced by both tumor cells and tumor-associated myeloid cells or TAMs also induced constitutive activation of STAT3 in tumor ECs, underscoring a central role of STAT3 signaling in mediating multidirectional crosstalk among tumor cells, myeloid cells and ECs in the TME that contributes to tumor angiogenesis [95]. This evidence concerns the gene STAT3 and neoplasm.