CBS and hyperlipidemia: The enzyme activity profiling for homocysteine transsulfuration in the liver where the lipid metabolism and homocysteine metabolism take place showed that hyperlipidemia led to a significant decrease in CBS activity (−44% vs. control group, p < 0.01) (Figure 2B) and CSE activity (−19% vs. control group, p < 0.001) (Figure 2C) in the liver, indicating impaired homocysteine transsulfuration to cysteine.