As shown in Figure 5D, the density of total MMP-9 in monocytes (888 ± 133) and macrophages (2524 ± 248) from RA patients’ peripheral blood with CypA stimulation was higher than that in the control group (329 ± 49 in monocytes, 1,052 ± 206 in macrophages; P <0.001), and decreased markedly when adding sdAbA1 (337 ± 58 in monocytes, 987 ± 103 in macrophages; P <0.001) or CsA (345 ± 54 in monocytes, 996 ± 192 in macrophages; P <0.001). Here, PPIA is linked to rheumatoid arthritis.