On the basis of immunohistochemical studies, with a certain level of receptors for estrogen, progesterone, and proliferative marker Ki-67, it is an undoubted fact that the carcinogenesis of endometrial tumors plays an important role not only on the hormonal status (hormone levels in the blood), but also on the so-called receptor imbalance directly in the endometrium. The gene discussed is MKI67; the disease is endometrium neoplasm.