Because of these receptor-negative stromal cells, endometrial polyps may relatively be insensitive to cyclic hormonal changes [32]; while the concentrations of ER and PR in glandular epithelium were higher in polyps than in the normal endometrium, the concentrations of these receptors in the glandular epithelium and stroma are similar in the post-menopausal and pre-menopausal patients. Here, ESR1 is linked to endometrial polyp.