Exploring the therapeutic implications of attenuating ER stress, treatment of A53T α-synuclein mice and a viral-vector mediated rat of α-synucleinopathy with Salubrinal, a pharmacological inhibitor of ER stress induced toxicity, dramatically delayed the onset of motoric symptoms and decreased accumulation of α-synuclein oligomers in vivo. The gene discussed is SNCA; the disease is synucleinopathy.