Further exploring the ER-associated chaperone Grp78/Bip as a therapeutic target, Gorbatyuk et al. recently showed that overexpression of this chaperone in the substantia nigra of a viral-vector mediated rat model of synucleinopathy attenuated α-synuclein-induced neurotoxicity by reducing ER stress mediators [161]. The gene discussed is SNCA; the disease is synucleinopathy.