SNCA and Parkinson disease: Similarly, while TorsinA was found to be a potent suppressor of α-synuclein aggregation and toxicity in cellular models [79] and in a Caenorhabditis elegans model [93], an elegant recent study using both an MPTP-induced mouse model of PD and α-synuclein transgenic mice could not detect a neuroprotective effect for overexpression of TorsinA [94].