Small molecule inhibitors of the Wnt pathway have disrupted the maintenance of MM cells both in vitro and in vivo providing the possibility of developing Wnt-targeted inhibitors for clinical treatment of MM [44,45] gp96 is a molecular chaperone in the endoplasmic reticulum and it is regulated by the unfolded protein response pathway [46]. This evidence concerns the gene HSP90B1 and Miyoshi myopathy.