To verify the role of caspase 3 in neurodegeneration, neurogenesis, synaptic plasticity, and astrogliosis during the early phase of epileptogenesis, the specific inhibitor of caspase 3 was applied onto an SE-induced epilepsy model which kainic acid (KA) is administered via intracerebral ventricle (icv) injection. Here, CASP3 is linked to epilepsy.