CLOCK and metabolic syndrome: It should be noted that although some of these mutant mice demonstrate disrupted locomotion and feeding behaviors (i.e., wrong-time feeding), the abnormalities seem to be attributable to mutations in the circadian clock machinery rather than to appropriate feeding times because mice (e.g., Bmal1 mutant mice) that do exhibit normal activity/feeding patterns still exhibit markers of metabolic syndrome (Lamia et al. 2008; Marcheva et al. 2010).