SIN3B and alcohol dependence: Conversely, transcripts of the gene MBD3, which encodes a key player in TCCs called methyl-CpG–binding protein, as well as many other TCC genes, such as SIN3A, SIN3B, player in TCCs called methyl-CpG– binding protein, as well as many other TCC genes, such as SIN3A, SIN3B, MTA1, MTA2, RBBP4, GATAD2A, GATAD2B, and CHD4 were upregulated in alcoholics (Liu et al. 2006; Ponomarev et al. 2012; Zhou et al. 2011).