BRCA2 and breast cancer: It was in agreement with approximately all of ethnics and population especially Asian BC families compared to non-BRCA1 and -BRCA2 mutations, and also among the BRCA1 and BRCA2 alterations, BRCA1 mutations are associated with higher tumor grade, P53 mutations and higher basal cell markers including cytokeratin [150, 151] and P-cadherin expression while underexpression of E-cadherin in triple negative BC cases of younger ages (estrogen, progesterone, and Her2 receptors) and eventually weaker prognosis [116, 152].