Although two of the frequent mutations (6503delTT and 3398delAAAAG) take place in ovarian cancer critical region (OCCR) located in exon 11 of BRCA2, there is no difference in risk of ovarian cancer among the carriers of theses mutations and others which are carriers of mutations in other part of BRCA2 gene [76]. The gene discussed is BRCA2; the disease is ovarian carcinoma.