BRCA2 and ovarian cancer: A domain binding single-stranded DNA containing 3 oligonucleotide-binding (OB1-3) folds and a helix-turn-helix motif that binds double stranded DNA is located in C-terminal segment of BRCA2. Moreover, there is a region in the 3′ end of BRCA2 gene, in exon 11, called ovarian cancer cluster region (OCCR) which may increases the risk of ovarian cancer in BRCA2 families if become mutated [16, 17].