Another study [116] reported that a PLP-specific clonotype persisted in the activated T-cell compartment of 1 of 2 patients with relapsing-remitting MS for >1 year; although the majority of clonotypes from both patients could be detected only transiently, this study did not attempt to correlate the clonotypes with disease activity. Here, PLP1 is linked to relapsing-remitting multiple sclerosis.