PLP1 and myeloid sarcoma: The earliest of these studies investigated T-cell reactivity to overlapping PLP peptides covering the whole length of PLP in 10 patients with monocentric monophasic demyelinating syndromes suggestive of a first attack of MS [115], and the second investigated T-cell reactivity to pooled PLP peptides and other antigens in 5 patients with the opticospinal form of MS and 6 patients with conventional MS [118].