Although hyperinsulinemia was previously reported in male C57BL6 ANXA1 KO mice on chow diet [16], in our study chow-fed female Balb/c ANXA1 KO mice only showed a non-significant trend towards elevated plasma insulin, a discrepancy likely attributable to strain- and sex-specific differences. The gene discussed is ANXA1; the disease is hyperinsulinism.